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Hi, The first thing I would say is that pixel cross-talk reduction is a very complex and application-specific engineering challenge that will likely require expertise in digital signal processing and optics. Therefore, it would probably be beyond the level of support you will find on this forum (which focuses more on Xilinx tool and hardware specific issues).
I assume you are building a camera. The kind of algorithm and parameters you choose will depend on what kind of sensor you are using (single sensor CMOS with bayer pattern vs 3 CMOS with prism), what the exact characteristics of the sensor / color filers are, which would need to be rigorously profiled. Then you have the issue that measuring crosstalk in realtime is also a content-dependent problem, as higher frequency information in one color channel will drastically affect your ability to correctly compensate for crosstalk into another channel.
Here are a few of resources to get you started understanding the problem more: