The answer my friends is Yes! I wanted to help shead somelight on an answer that was baried in another post.
If you are trying to install a 32-bit only tool on a 64-bit OS you will always have to go into the bin\nt or bin\lin folder and run the installation from there.
If you download the single file install and simply run xsetup, the software installs both 32bit and 64bit ISE when installing on a 64bit XP platform.
Have fun and good luck.